A major effect of lowering [Mg2+]o appears to be a down-regulation of SM synthase.
The synthesis of sphingomyelin involves the enzymatic transfer of a phosphocholine
from phosphatidylcholine to a ceramide.
The first committed step of sphingomyelin synthesis involves the condensation
of L-serine and palmitoyl-CoA.
鞘磷脂的合成涉及磷酸膽鹼從磷脂醯膽鹼到神經醯胺的酶促轉移。
鞘磷脂合成的第一步是將L-絲氨酸和棕櫚醯輔酶A縮合。
This reaction is catalyzed by serine palmitoyltransferase.
絲氨酸棕櫚醯轉移酶催化該反應。
The product of this reaction is reduced, yielding dihydrosphingosine.
The dihydrosphingosine undergoes N-acylation followed by desaturation to yield a ceramide.
該反應的產物被還原,產生二氫鞘氨醇。 二氫鞘氨醇經歷N-酰化,然後去飽和以產生神經醯胺。
Palmitoyl-CoA is a coenzyme A derivative of palmitate formed by acyl-CoA synthase.
棕櫚醯輔酶A是由醯基輔酶A合酶形成的棕櫚酸酯的輔酶A衍生物。
脹氣怎麼治總整理Part-II(腸胃蠕動的真相,缺鎂鋅硒維它命ABC,建議一天一粒善存+豆漿)
告訴我們:
硒參與輔酶A的合成
Acetyl-CoA (AcCoA) synthetase (Acs)
乙醯輔酶A(AcCoA)合成酶(Acs)
Acs活性[14]所需的Mg2+(鎂)可以被Ca2+(鈣)和Mn2+(錳)取代
Evidence for a single non-arachidonic acid-specific fatty acyl-CoA synthetase in heart which is regulated by Mg2+
心臟中受Mg2+(鎂)調節的醯基輔酶A合成酶的證據
小結2:
所以還需要絲胺酸當原料及礦物質硒。
serine in vegetables for the top 20 vegetables.
絲氨酸含量排名前20名的蔬菜。
Soybeans, Lentils,Spinach
大豆,扁豆,菠菜
所以需要喝豆漿
總結以上:
建議補充維生素K、維生素C、錳,鈣和鎂、絲胺酸、硒來合成神經鞘磷脂。